COQ8B and kidney failure: Specifically, in a sibling case, the younger sister (patient 8-2) with COQ8B His174/Arg174 exhibited a later age of SRNS onset and maintained normal kidney function to the age of 5.1 years, whereas the older brother (patient 8-1) with COQ8B His174/His174 progressed to kidney failure at the age of 1.3 years.