Figure 1(a) shows the fitting curve of the annual trend of the number of papers published. Annual Np is not related to the year of publication. As can be seen from Figure 1(a), the correlation coefficient R2 was only 0.768. Figures 1(a) and 1(b) show the annual Np associated with NF-κB in melanoma. This evidence concerns the gene NFKB1 and melanoma.