Among the three groups, PDB patients had a median sclerostin level of 291.60 pmol/L (interquartile range: 153.42-357.35 pmol/L), XLH patients had a lower median sclerostin level of 163.40 pmol/L (interquartile range: 125.10-238.20 pmol/L), and OI patients had a lowest median sclerostin level of 130.50 pmol/L (interquartile range: 96.12-160.80 pmol/L) (Table 5 and Figure 1). The gene discussed is SOST; the disease is osteogenesis imperfecta.