There were no differences regarding serum sclerostin levels between genders in OI and PDB [male vs. female, 127.30 (95.68-151.80) vs. 130.50 (101.84-176.65) pmol/L and 294.00 (199.68-364.80) vs. 218.80 (128.42-316.60) pmol/L, respectively, all P > 0.05]. The gene discussed is SOST; the disease is osteogenesis imperfecta.