Also, a 50 pmol/L increase in sclerostin was associated with an OR of 2.602, 4.500, and 2.166 for having OI (OR = 2.602, 95% CI, 1.833 to 3.693), XLH (OR = 4.500, 95% CI, 2.653 to 7.631) and PDB (OR = 2.166, 95% CI, 1.227 to 3.826). The gene discussed is SOST; the disease is osteogenesis imperfecta.