Moreover, recent preclinical studies on breast cancer also found that the overexpression of lncRNA miR210 host gene (MIR210HG) increased the level of HIF-1α protein, acted as a tumor promoter by enhancing the Warburg effect, and combined cytotoxic chemotherapy with drug therapy targeting hypoxia-inducible factor to significantly improve the clinical outcome of patients [31, 32]. Here, HIF1A is linked to neoplasm.