Yang et al. found that corticosteroids inhibited the alveolar structure destruction, infiltration of neutrophils, and the inflammatory cytokines release of IL-1β and IL-18 in lung by suppressing both NF-κB signal pathway and mtROS-dependent NLRP3 inflammasome activation in LPS-induced murine ALI model [43]. This evidence concerns the gene IL1B and acute respiratory distress syndrome.