Another possible pathway that might be implicated in the observed ‘inhibition delay’ is modulation of RhoA/ROCK signalling that has been reported to induce tenascin-C transcription in chick embryo fibroblasts [34]; this has direct implication as tenascin-C remodelling has been previously reported to be strongly associated with elevated IOP in glaucoma [35]. Here, RHOA is linked to glaucoma.