CCNB1 and hepatocellular carcinoma: In particular, studies have shown that CCNB1 and CDK1 are important molecules involved in cell proliferation and cell cycle which were closely related to mitosis.[16] Zou et al indicated that mRNA expression of CDK1 and CCNB1 was upregulated in hepatocellular carcinoma (HCC) and the higher the expression of these genes the poorer the prognosis of the HCC patients.[17] High expression of CDK1 was also detected in lung cancer and pancreatic and colorectal cancer[18–20] and was associated with the prognosis of the patients.