It plays an important role in the regulation of cell cycle progression since it is a regulatory subunit of CDK1.[21] Numerous studies showed that dysregulation of CKS2 may contribute to the growth and metastasis of tumors in breast cancer, ovarian cancer, hepatocellular carcinoma, non-small-cell lung cancer, and colorectal cancer.[22–26] CCNA2, CCNB1, CDK1, and CKS2 are key molecules involved in the cell cycle and play a crucial role in tumorigenesis and cancer progression. This evidence concerns the gene CDK1 and hepatocellular carcinoma.