It is a mitotic phosphorylation protein regulated by the ubiquitin-proteasome pathway and a vital regulator of the integrity and differentiation of adhesion molecules.[27] MAD2L1 is an important component of the spindle checkpoint and plays a role in overseeing chromosome segregation during mitosis.[28] As key elements of the cell cycle, DLGAP5 and MAD2L1 are closely related to tumor development, especially in the spindle assembly which is one of the main development directions of chemotherapy.[29]. This evidence concerns the gene MAD2L1 and neoplasm.