As shown in Figure 6, AKT is the core target of the PI3K-AKT signaling pathway, and its up-regulation may be associated with EMS pathogenesis.[34] It will act on the important tumor gene MDM2 proto-oncogene, and MDM2 proto-oncogene will affect the TP53 gene transcription protein P53 via the P53 signaling pathway.[35,36] According to the research,[37] the positive rate of P53 protein produced by TP53 gene in normal human endometrial tissue is higher than that in abnormal endometrial tissue from Ovarian endometriosis cyst patients. Here, MDM2 is linked to eosinophilia-myalgia syndrome.