MDM2 and neoplasm: As shown in Figure 6, AKT is the core target of the PI3K-AKT signaling pathway, and its up-regulation may be associated with EMS pathogenesis.[34] It will act on the important tumor gene MDM2 proto-oncogene, and MDM2 proto-oncogene will affect the TP53 gene transcription protein P53 via the P53 signaling pathway.[35,36] According to the research,[37] the positive rate of P53 protein produced by TP53 gene in normal human endometrial tissue is higher than that in abnormal endometrial tissue from Ovarian endometriosis cyst patients.