The results of the meta-analysis implied that high securin expression was positively correlated with unfavorable overall survival (OS) (hazard ratio = 1.52, 95% CI, 1.33–1.73; P < .001) and lymph node metastasis (odd ratio = 2.96, 95% CI, 2.26–3.86; P < .001). This evidence concerns the gene PTTG1 and metastatic malignant neoplasm in the lymph nodes.