M1-type macrophages release cytokines that inhibit the proliferation of surrounding cells, destroy adjacent tissues, and exhibit antitumor activity.[41,42] In contrast, M0-type macrophage infiltration is characteristic of glioblastoma malignancy.[43] Next, by examining the correlation between SLC22A8 expression and immune status, we were surprised to find that 14 immune functions and immune cell scores, including CCR, macrophages, parainflammation, T helper cells, TILs, and Tregs, were significantly higher in the low expression group than in the high SLC22A8 expression group. This evidence concerns the gene SLC22A8 and glioblastoma.