SLC22A8 and nonpapillary renal cell carcinoma: In the Cox proportional hazards regression model, we found that OS was significantly affected by some factors in both the univariate and multivariate analyses, including age (P < .001 in univariate analysis, P = .047 in multivariate analysis), M stage (P < .001 in univariate analysis, P = .002 in multivariate analysis), and high expression level of SLC22A8 (P < .001 in univariate analysis, P = .007 in multivariate analysis), which were considered independent prognostic factors for ccRCC patients (Table 3).