The results indicated that low SLC22A8 levels were enriched in B cells (P = .00025), basophils (P = 1.2e–06), CD4 + memory T cells (P = 2.1e–05), CD8 + T cells (P = 1.1e–05), eosinophils (P = .0027), macrophages (P = 5.9e–07), mesenchymal stem cells (P = .0016), regulatory T cells (P = .00023), type 1 T helper cells (P = .0013), natural killer T cells (P = .049), and type 2 T helper cells (P = .021) with worse OS in ccRCC (Fig. S4, Supplemental Digital Content, http://links.lww.com/MD/H123). This evidence concerns the gene CD4 and nonpapillary renal cell carcinoma.