IGF1 and hyperinsulinism: Hyperinsulinemia leads to an increase in the bioactivity of IGF-1 by inhibiting IGF binding protein-1.[10] Mitogenic and antiapoptotic activity of mature IGF-1, as well as different transcripts and precursor IGF-1 peptides, qualify IGF-1 to the group of growth factors implicated in the initiation and progression of various cancers.[11] High glucose serves as a subordinate plausible explanation of carcinogenesis.