And 1 study also shown that SOX9 mediates Notch1-induced mesenchymal features in lung adenocarcinoma.[15] In accordance with its function, large amounts of studies have explored the function of SOX9 expression in hepatocellular carcinoma, breast cancer, prostate cancer, lung cancer, esophageal cancer and colorectal cancer.[22,48–54] Moreover, a previous study found that H. pylori induces SOX9 expression in pretumorigenic gastric mouse cells.[11] Most recently, SOX9 expression also have received widespread attention in GC. This evidence concerns the gene SOX9 and esophageal cancer.