Zu et al[34]explained the relationship between SOX9 and the prognosis of gastrointestinal cancer by a meta-analysis, which included eleven studies, found no significant association between SOX9 and clinicopathological characteristics of GC (age, sex, differentiation, lymph node metastasis), the conclusions were weakened. This evidence concerns the gene SOX9 and metastatic malignant neoplasm in the lymph nodes.