AKT1 and ovarian clear cell cancer: PIK3CA is the catalytic subunit of the class I PI3-kinase enzyme part of the PI3K/AKT/mTOR pathway.[37] It plays a role in cell growth, motility, survival, proliferation, protein synthesis, autophagy, transcription, and angiogenesis.[24] Most studies agree that the primary molecular genetic alteration that activates the PI3K/AKT pathway in ovarian clear cell carcinoma is PIK3CA mutation.