These results were found that (1) ApoH−/− mice developed spontaneous steatohepatitis, and those fed an alcohol diet had severe hepatic steatosis, and (2) alcohol downregulated ApoH expression in the liver, activating metabolic pathways, promoting hepatocyte steatosis, and inducing gut microbiota dysbiosis in mice (Fig. 6). This evidence concerns the gene APOH and Hepatic steatosis.