In particular, this study demonstrated that the decreased CD3+CD4+ T cells (≤ 288cells/ul) were an independent risk of cardiac injury in DM patients with COVID-19 (adjusted OR, 2.501; 95% CI, 1.282–4.877; p = 0.007; Pinteraction = 0.018), but not in patients without DM (Fig. 5). The gene discussed is CD4; the disease is COVID-19.