After adjusting age, sex, CRP, LDL-c, the presence of comorbidities (included hypertension and coronary heart disease), coagulopathy, and glucocorticoid therapy, the independent predictors for cardiac injury in DM patients were IL-10 > 5.71 pg/ml (adjusted OR, 4.582; 95% CI 1.606–13.075; p = 0.004) and NLR > 7.525 (adjusted OR, 3.426; 95% CI 1.930–6.080; p = 0.002), with no detectable evidence of interaction with DM (Pinteraction > 0.05). The gene discussed is CRP; the disease is Hypertension.