Considering HPV-positive metastases, the density of intra-tumoral CTLA-4+ T cells and the percentage of PD-L1+ macrophages interacting with PD-1+ T lymphocytes within the tumor regions were higher in females than in males, while the percentage of HLA-I negative tumor cells was lower (Supplementary Fig. S5B). Here, PDCD1 is linked to neoplasm.