The analysis of CD8+ T cell subsets revealed that CD8 + CD103+, CD8 + PD-1+ and CD8 + CD103 + PD-1+ T lymphocytes were present at higher densities in HPV-positive than HPV-negative metastases, both in the stroma and within the tumor cell nests (Fig. 5B). Here, PDCD1 is linked to neoplasm.