Gene expression-based cell type profiling revealed that HPV-positive OPSCC had an increased infiltration of CD45 cells, and in particular of total tumor infiltrating lymphocytes (TILs), CD8 T cells, cytotoxic cells, exhausted CD8 cells and macrophages, and a decrease in neutrophils infiltration (Fig. 1C and Supplementary Fig. S1B). The gene discussed is CD8A; the disease is neoplasm.