From the initial cohort of 6,816 IVF/ICSI cycles, 1,580 cycles were excluded from the analysis for the following reasons: female age > 40 years, basal FSH > 10 mIU/ml, AMH < 1.1 ng/ml, antral follicle count (AFC) < 7, 18 ≤ BMI ≤ 28 kg/m2, uterine anomalies, and polycystic ovary syndrome (PCOS). This evidence concerns the gene BRD2 and polycystic ovary syndrome.