Consistent with the above findings, in the present study, we showed that both AP2α and AP2β proteins were overexpressed, and there was a positive correlation between USP22 and AP2 proteins in lung cancer tissues, and we also demonstrated that knockdown of TFAP2A and TFAP2B significantly suppressed the proliferation and invasion potential of lung cancer cells. This evidence concerns the gene TFAP2A and lung carcinoma.