Activation of APCs, such as conventional dendritic cells (cDCs), macrophages, and B cells, via TLR agonism can enhance tumor antigen uptake and presentation of said antigens on MHC to helper CD4+ and cytotoxic CD8+ T cells [32] as well as recruit and activate innate cytotoxic lymphocytes such as NK cells. The gene discussed is CD8A; the disease is neoplasm.