To address the upregulation of LAG3 and TIGIT induced by the treatment of NBTXR3 + XRT + αPD1, we established a two-tumor model with 344SQR αPD1-resistant lung cancer in mice, which were subsequently treated with various combinations of radiation (XRT), XRT enhanced with NBTXR3, αPD1, αLAG3, and αTIGIT (Fig. 1A). Here, LAG3 is linked to neoplasm.