These included: Irf7; interferon-stimulated genes Isg15 and 20; complement factor B (Cfb); Axl, a receptor tyrosine kinase that facilitates immune evasion and metastasis in various cancers [33, 34]; dual specificity phosphatases Dusp6 and 8; and Map2k1, which is frequently dysregulated in cancer and is the target of numerous experimental inhibitors being developed [35]. This evidence concerns the gene ISG15 and cancer.