Furthermore, similar DNA amplification profiles were found for 10 PSM genes located on the same cytoband (PSMB5 and PSMB11, 14q11.2; PSME1 and PSME2, 14q12; PSMC4 and PSMD8, 19q13.2; PSMB4 and PSMD4, 1q21.3; PSMB8 and PSMB9, 6p21.32; Supplementary Fig. 2) and a number of consensus cancer driver genes (e.g. PSMB3 and ERBB2, 17q12; PSME3 and BRCA1, 17q21.31) [43, 44]. This evidence concerns the gene PSMB4 and cancer.