In conclusion, the comprehensive pan-cancer analysis presented here demonstrated that several PSM genes (e.g. PSMA1, PSMB4-5, PSMB8-10, PSMD2, PSMD4, PSMD11, PSME1-3, and PSMG3) may be putative biomarkers for determining prognosis and choice of treatment for different cancer types. Here, PSME1 is linked to cancer.