Although missense mutations spanned the PSME4 gene, 14 cancer samples (colon adenocarcinoma (COAD, n = 2), stomach adenocarcinoma (STAD, n = 6), and uterine corpus endometrial carcinoma (UCEC, n = 6)) had truncating mutations in a domain at the C-terminal region with unknown function (10 with frameshift deletion in T1805Pfs*69, three with frameshift insertion in T1805Nfs*11, and one sample with missense in T1805P; Fig. 2G). The gene discussed is PSME4; the disease is cancer.