Specifically, we found that expression of NR1H4 was significantly correlated with chemokine (C–C motif) ligand (CCL)-2, CD68, IL10 of TAMs, especially CD163, VSIG4 and MS4A4A of M2 Macrophage in ccRCC (P < 0.001) (Fig. 7B-E). This evidence concerns the gene VSIG4 and nonpapillary renal cell carcinoma.