Alternative phenotypic manifestations of RYR1 variants have been speculated as predisposing to neuroleptic malignant syndrome (NMS) [23, 24], serotonin syndrome [25], stimulant abuse [26, 27], parkinsonism-hyperpyrexia syndrome [28], sepsis [29], toxicity of uncoupling agents dinitrophenol and aspirin [30], and others [31–33]. The gene discussed is RYR1; the disease is neuroleptic malignant syndrome.