IL-22 (F-652) protects against LPS-induced cytokines storm in the LPS-induced endotoxemia model by inducing the expression of APPs from the liver, like S100A9, and thereby inducing F4/80+Ly6GhiLy6Chi M2-like suppressor cells differentiation. The gene discussed is S100A9; the disease is serum lipopolysaccharide activity.