INS and Hypoglycemia: In general, the amount of parenteral glucose given during the first week in ICU by maintenance solutions may not exceed the equivalent amount of 1 ml dextrose 5% per kg per hour, unless the patient develops spontaneous hypoglycemia (hypoglycemia while not on insulin treatment) or has high risk to do so (e.g., in acute liver failure), or when the patient has a need for high volumes of hypotonic fluids (e.g., severe hypernatremia due to fluid losses).