Significant differences were found in weight of all participants (p ˂0.001) and obese subjects (p = 0.008), waist circumference of individuals with obesity (p = 0.03) and all subjects (p = 0.001) and WHR of all participants (p = 0.02) between different genotypes of MC4R. The gene discussed is MC4R; the disease is obesity due to melanocortin 4 receptor deficiency.