In addition, the knockdown of GBA effectively induced apoptosis in HCC cells by increasing the percentages of early-stage and late-stage apoptotic cells (both HepG2 and MHCC-97H cells, P < 0.01; Fig. 2c, Supplementary Fig. 2d and Supplementary Fig. 2g). Here, GBA1 is linked to hepatocellular carcinoma.