Similarly, the statistical results based on the TCGA dataset revealed that dramatic overexpression of GBA was significantly associated with high age (P = 0.02), the presence of metastasis (0.01 < P < 0.05) and vascular invasion (P = 0.04), and a short overall survival time (P = 0.01) in HCC patients (Supplementary Table 2). This evidence concerns the gene GBA1 and hepatocellular carcinoma.