Notably, in tumor samples, the protein levels of LC3B and SQSTM1/p62 were increased but the level of GBA was reduced by ART (Fig. 7a, b), and both of these changes were reversed by LTI-291 (Fig. 7a, b), implying an association between the anticancer effects of ART and GBA-mediated autophagic degradation. The gene discussed is SQSTM1; the disease is neoplasm.