Interestingly, despite low expression of these gene sets was observed in PL of PT2, relatively high expression of APC abundance and IFN activity were enriched in corresponding DLNs, and this patient only had 16% residual tumor left in the PL, which might indicate an underlying role of inflamed phenotype in DLNs for promoting the efficacy of immunotherapy (Fig. 4a). This evidence concerns the gene IFNA1 and neoplasm.