In ICC patients, the genes with HBV integrations in more than 1 tumor samples were TERT (4), ZMAT4 (2), MET (2), ANKFN1 (2), and PLXNB2 (2); while in non-tumor tissues, only FN1 contained HBV integrations in 2 samples, which is consistent with the results of our previous study of HCC [24]. This evidence concerns the gene PLXNB2 and intrahepatic cholangiocarcinoma.