For CHC patients, TERT and ALKBH5 are found to be integrated by HBV fragments in 4 tumors and 2 tumors respectively; interestingly, FN1 is also the only gene with HBV integration event occurred in more than 2 non-tumor samples, which is consistent with the results of ICC samples (Fig. 2a, b). This evidence concerns the gene FN1 and cryohydrocytosis.