Xenograft experiments revealed that YAP co-expressed with Mycn and SOX10 significantly increased tumor volume, whereas this effect could be reversed by NSUN2 and ALYREF knockout; also, YAP co-expressed with NSUN2 and ALYREF significantly raised tumor volume, and this effect could be reversed by GW4869 treatment (Fig. 6E–H). The gene discussed is ALYREF; the disease is neoplasm.