A 2020 study suggested that IL17A deficiency in chronic colitis upregulates IL6 expression and leads to the recruitment of RORγt + innate lymphoid cells in a negative feedback loop; the authors proposed this mechanism to explain the discrepancies between the insensitivity of IL17A-KO mice to acute colitis and the otherwise negative correlation between IL17A and worsening symptoms67. This evidence concerns the gene IL17A and Chronic colitis.