One of the key processes involved in cancer development is that cancer cells acquire immune escape by inducing and recruiting immunosuppressive cells, such as Treg cells, bone marrow-derived suppressor cells, and tumor-associated macrophages, as well as increasing the expression of various immunosuppressive molecules, such as PD-1 and PD-L1 (PD-L1). This evidence concerns the gene CD274 and neoplasm.