In mouse models, the depletion of BIN1 has been confirmed to induce IDO expression and immune suppression in tumors.497 IDO can enhance the motility of cancer cells and inhibit the proliferation and function of tumor-targeting T cells.498 Mouse xenograft models show that treatment with IDO inhibitors can significantly increase the level of T cells and have a significant tumor-suppressive effect. The gene discussed is IDO1; the disease is neoplasm.