In NSCLC tissues, high expression of NR2F6 was detected in tumor-infiltrating lymphocytes (TILs), and upregulated NR2F6 expression was associated with impaired production of cytokines, including IL-2, TNF-α, and IFN-γ,185 suggesting that NR2F6 on TILs contributes to tumor immunosuppression. The gene discussed is TNF; the disease is neoplasm.