CD96 and neoplasm: It was found that CD96 expression on tumor-infiltrating NK cells was higher than that on NK cells in surrounding tissue.252 Higher levels of CD96 expression on NK cells in hepatocellular carcinoma samples predicted poor prognosis.253 Preclinical results in tumor models with implantable or spontaneous metastases have proven that CD96 inhibitors can reduce metastatic potential,187,254 which supports the future clinical application of agents with this target.