CD39 expression in MDSCs is positively correlated with NSCLC tumor stage, but its function remains unknown.511 Due to its important role in the TME, CD39 has become an emerging target for researchers to develop tumor immunotherapy.512,513 In vivo and in vitro data suggest that targeting CD39 sensitizes tumors to PD-1/PD-L1 ICB treatment. This evidence concerns the gene ENTPD1 and non-small cell lung carcinoma.