Nuclear receptor subfamily 2 group F member 6 (NR2F6) was recently reported as an intracellular IC molecule, which is an orphan nuclear receptor inherent to lymphocytes.183,184 NR2F6 acts as a transcription factor regulating the activation, recruitment, proliferation, and homeostasis of cells associated with tumor antigen-specific T-cell responses. This evidence concerns the gene NR2F6 and neoplasm.