CD47, also known as integrin-related protein, belongs to the immunoglobulin superfamily, which regulates cell proliferation, migration and apoptosis by binding to signal regulatory protein α (SIRPα) on the surface of macrophages or dendritic cells.464 CD47 is overexpressed on the surface of most tumor cells as a “do not eat me” signal that escapes phagocytosis by macrophages. Here, CD47 is linked to neoplasm.