CTNNB1 (coding for β-catenin) (22% mutation rate) and TP53 (29% mutation rate) are the most frequently altered proto-oncogenes and tumor suppressor genes, respectively, detected mainly in HCC (https://cancer.sanger.ac.uk/cosmic/browse/tissue?wgs=off&sn=liver&ss=all&hn=all&sh=all&in=t&src=tissue&all_data=n) (4). Here, CTNNB1 is linked to hepatocellular carcinoma.