Furthermore, Pri-724 reduced AKT2 expression in β-catenin–mutated MEFs, HepG2, and Hepa 1-6 cells as well as in human HCC cells (M97h and Huh7) (Fig. 4 H and J and SI Appendix, Fig. S7E). The gene discussed is AKT2; the disease is hepatocellular carcinoma.