Importantly, the dual-luciferase reporter assay determined that miR-137 directly bound to the 3′ UTR of LGR4. So far, only two studies have reported the binding of LGR4 by miR-137 in prostate cancer cells (Zhang et al., 2020), U-2 and MC3T3 cells (Liu and Xu, 2018). Here, LGR4 is linked to Familial prostate cancer.