Moreover, anti-PGRN-treated mice exhibited attenuated kidney injury with a significant reduction in the expression of KIM-1 at days 4, 7 and 9 after C. albicans infection (Fig 6F), as well as significantly lower serum concentrations of urea (Fig 6G) and creatinine (Fig 6H) at days 7 and 9 after infection. This evidence concerns the gene HAVCR1 and infection.