CXCL1 and infection: In agreement with reduced renal inflammation in PGRN KO mice by histopathological analysis (S1C Fig), at early time points of infection (days 1, 4 and 7) when similar fungal burden was observed in WT and PGRN KO mice (Fig 2E–2G), we found that kidney IL-6, CXCL1 and CCL2 levels in PGRN KO mice were significantly lower than those in WT mice (Fig 4A).