In fact, PGRN has been shown to be able to inhibit Th1 and Th17 cells, and significantly lower levels of INF-γ and IL-17 were observed in PGRN-deficient mice compared with WT mice in experimental autoimmune encephalomyelitis, experimental autoimmune uveitis or coxsackievirus-B3-induced viral myocarditis [42–44]. Here, IL17A is linked to experimental autoimmune encephalomyelitis.