Compared with WT mice, PGRN KO mice exhibited attenuated kidney injury with a significant reduction in the expression of renal KIM-1 at days 4, 7 and 9 after infection (Fig 5C), as well as significantly lower serum levels of urea (Fig 5D) and creatinine (Fig 5E) at days 7 and 9 after infection. This evidence concerns the gene GRN and infection.