GRN and infection: Anti-PGRN treatment also led to significantly reduced protein levels of IL-6, CXCL1, and CCL2 in the kidneys at days 1, 4, 7, and 9 after infection (Fig 6D), and these animals had significantly lower numbers of infiltrating F4/80+ macrophages and Ly-6G+ neutrophils compared with mice treated with control IgG at days 4, 7 and 9 after C. albicans infection (Fig 6E).