GRN and abscess: Histopathological analysis showed that WT kidneys had numerous multifocal areas of abscess formation and manifested increased renal inflammation compared with PGRN KO kidneys at days 4, 7, and 9 after invasive C. albicans infection (S1C Fig), which was reflected by significantly higher pathology scores in WT mice compared with PGRN KO mice (Fig 2D).