GRN and candidiasis: Despite that PGRN KO mice had similar fungal burden in the kidney, which is the primary infected organ in the systemic candidiasis mouse model, at the early times of C. albicans infection (days 1, 4, and 7), the production of proinflammatory cytokine IL-6, a major cause of sepsis [37,38], in PGRN-deficient mice was significantly lower than that in WT animals.