PGRN deletion also decreased the production of the macrophage and neutrophil chemokines CCL2 and CXCL1, and reduced the expression of adhesion molecules ICAM-1 and P-Selectin in the kidneys at early phases of infection, paralleling the decrease of macrophage and neutrophil recruitment to the infected kidneys in PGRN-deficient mice after IC. The gene discussed is CXCL1; the disease is infection.