We further determined the expression levels of additional inflammation mediators involved in acute kidney inflammation, including the major adhesion molecules: intercellular adhesion molecule 1 (ICAM-1) and P-Selectin, and we detected significantly reduced renal expression levels of ICAM-1 (at days 1, 4, 7, and 9) and P-Selectin (at days 4, 7, and 9) in PGRN KO mice compared with WT mice after C. albicans infection (Fig 4G). Here, GRN is linked to nephritis.