Angiotensin converting enzyme inhibitors (ACEIs) or angiotensin receptors blockers (ARBs) had no significant association with advanced CKD, possibly due to the small numbers on these agents, unlike findings from other studies that did demonstrate that the use of ACEIs/ARBs had beneficial effects for kidney events and cardiovascular outcomes compared to other antihypertensive medications in patients with CKD [63–65]. The gene discussed is ACE; the disease is chronic kidney disease.