Different studies report both a decrease in Znt3 protein levels in the spinal cords of ALS patients (Kaneko et al. 2015) and a significant loss of synaptic vesicular zinc with a decline in ZnT3 transcriptional activity in Huntington's disease (HD) transgenic mice (Niu et al. 2020). This evidence concerns the gene SLC30A3 and amyotrophic lateral sclerosis.