A prospective pilot case–control trial is ongoing (NCT04148716) that evaluates miRNA profiles in SSc tissues and in particular is evaluating pro-fibrotic “key” miRNAs called FibromiRs (miR-199a-3p, miR-199a-5p, and miR-214) associated with monitoring the response to TGF-β in fibroblasts. Here, TGFB1 is linked to systemic sclerosis.