TGFB1 and systemic sclerosis: miR-21 exert key roles in the pathogenesis of fibrosis and cancer: in SSc miR-21 enhances TGF-β signalling inducing fibrosis [109] and additionally miR-21 is one of the first oncomiRs found upregulated in several cancers and represents a plausible diagnostic and prognostic biomarker, as well as a therapeutic target [110].