Numerous chaperones and co-chaperones, including Hsp90 and Hsp70, co-localize with Lewy bodies and in the brains of PD and DLB patients, Hsc70 and Hsp90 protein levels are increased in insoluble tissue fractions and correlate with insoluble α-synuclein deposition [121]. This evidence concerns the gene HSP90AA1 and Lewy body dementia.