Numerous chaperones and co-chaperones, including Hsp90 and Hsp70, co-localize with Lewy bodies and in the brains of PD and DLB patients, Hsc70 and Hsp90 protein levels are increased in insoluble tissue fractions and correlate with insoluble α-synuclein deposition [121]. Here, HSP90AB1 is linked to Parkinson disease.