CASP3 and Zika virus infectious disease: Prolonged ER stress upon ZIKV infection, however, also triggers a particular type of nonapoptotic cell death characterized by the cytoplasmic formation of ER-derived vacuoles leading to paraptosis-like cell death (32); paraptosis was firstly defined by morphological criteria and by occurring independently of the activation of cleaved-caspase 3 (cl-CASP3) (33).