2020). In addition, AS-IV can modulate multiple pathways involved in cell life and death (Zhang et al. 2020). Moreover, it can attenuate sepsis-induced intestinal barrier dysfunction by preventing oxidative stress inflammation and activating the NLRP3 inflammasome (Zhang and Frei 2015; Li et al. 2016; Zhu et al. 2019; Xie et al. 2020). Here, NLRP3 is linked to Sepsis.