Compared with normal esophageal normal tissues next to cancer, based on IPO5 expression in 6 pairs of esophageal cancer tissues and normal tissues, there was a significant upregulation of the expression level of IPO5 in tumor tissues, and cytoplasmic staining was primarily used to detect IPO5 (P < 0.05) (Figure 5). The gene discussed is IPO5; the disease is neoplasm.