IQGAP1 and cancer: Current studies on IPO5 are limited and are mainly focused on the following fields: Wnt pathway activity is involved in the development of various benign and malignant cancers, IPO5 interacts with IQGAP1, a regulatory factor of β -catenin, and loss of IPO5 reduces the expression of Wnt target genes during early embryogenesis [7]; human herpes virus 8 (HHV-8) can bind to IPO5mRNA, and the mechanism may be to induce the production of miRNA, leading to the pathogenesis of Kaposi's sarcoma [8].