Due to the unknown mechanism of miR-342-3p and its target SOX12 in AML, the motivation and novelty of this research is to survey the possible mechanisms by which miR-342-3p influences AML cell multiplication and apoptosis via targeting SOX12, aiming to decipher new mechanisms of AML genesis and development and provide a theoretical basis for seeking novel targeted therapies. This evidence concerns the gene SOX12 and acute myeloid leukemia.