Research has indicated that after SOX12 knockdown, β-catenin mRNA, and protein levels are dramatically reduced, and TCF/Wnt activity is reduced, which leads to G1 phase cell cycle arrest and decreased cell colonies, indicating that SOX12 may regulate β-catenin expression to interfere with the TCF/Wnt pathway and participate in leukemia progression [15]. The gene discussed is HNF4A; the disease is leukemia.