Zhou et al. assessed both neuropreventive (10, 20,or 40 mg/kg, intragavage (ig)) and neurotherapeutic effects of OEA (40 mg/kg, ig) in a mice model of ischemic stroke and concluded that orally administered OEA protects mice from focal cerebral ischemic injury particularly BBB disruption by activating PPAR-α [33]. Here, PPARA is linked to ischemic stroke.