Damage to the VAPB-PTPIP51 tethers is also seen in neurodegenerative diseases and so the use of neuronal SH-SY5Y cells is relevant in this context (Stoica et al., 2014; Stoica et al., 2016; Paillusson et al., 2017; Gomez-Suaga et al., 2022). The gene discussed is RMDN3; the disease is neurodegenerative disease.