Another vital finding of our study was that we constructed a prognostic signature using the LASSO Cox regression analysis with six PRGs with prognostic value (GSDMB, CASP9, GSDMD, CASP8, AIM2, and CASP1) and this prognostic signature showed a favorable performance for predicting the prognosis of bladder cancer patients. The gene discussed is CASP1; the disease is urinary bladder cancer.