PMEL and melanoma: We also examined the expression of other genes involved in melanin synthesis, such as Mlana, Pmel and Trpm1, which are considered as biomarkers for melanoma (Wang et al., 2011; Brozyna et al., 2017; Zhang et al., 2021) and the results showed that these genes were significantly upregulated as well in CKO mice (Supplementary Figure S3).