Furthermore, by using RNA-seq data from The Cancer Genome Atlas (TCGA) melanoma cohort (Tang et al., 2017), we found that the mRNA level of UFL1 was negatively correlated with those of well-known targets downstream from melanin biosynthesis pathway, including OCA2 and SLC45A2 (Figures 3C,D). The gene discussed is SLC45A2; the disease is melanoma.