We also compared the protein level data and found that PI3K pathway activators like TSC1, 4EBP1 and p4EBP1, PI3K-p85, RICTOR-pT1135 were significantly increased in high mesenchymal tumors, and PI3K inhibitor like LKB1 and INPP4B expression was significantly decreased (Supplementary Figure S3B) (Hoxhaj and Manning, 2020). This evidence concerns the gene TSC1 and mesenchymal cell neoplasm.