INPP4B and mesenchymal cell neoplasm: We also compared the protein level data and found that PI3K pathway activators like TSC1, 4EBP1 and p4EBP1, PI3K-p85, RICTOR-pT1135 were significantly increased in high mesenchymal tumors, and PI3K inhibitor like LKB1 and INPP4B expression was significantly decreased (Supplementary Figure S3B) (Hoxhaj and Manning, 2020).