YTHDF2 and cancer: As TME plays an important role in regulating tumor progression and could affect the response of immunotherapy, we calculated the correlation between YTHDF2 expression and immune scores (Supplementary Figure S6A), stromal scores (Supplementary Figure S6B), estimated scores (Supplementary Figure S6C) and tumor purity (Supplementary Figure S6D) in 32 cancers based on the ESTIMATE algorithm to assess the relationship between YTHDF2 expression and TME composition.