Expression analysis of the paired tumor and normal samples also demonstrated that the expression of YTHDF2 was dramatically upregulated in 16 cancer types including BLCA, BRCA, CHOL, COAD, ESCA, HNSC, LIHC, LUAD, LUSC, PRAD, STAD, THCA and UCEC, whereas downregulated only in KICH (Figure 1C). The gene discussed is YTHDF2; the disease is cancer.