We found that the abnormal YTHDF2 expression was negatively correlated with the promoter methylation values of CpG dinucleotides in most of the tumor types including BLCA, BRCA, CHOL, DLBC, ESCA, GBM, KICH, KIRP, LAML, LGG, LIHC, LUAD, LUSC, MESO, PAAD, PCPG, PRAD, READ, SARC, TGCT, UCEC and UVM, while positively correlated only in COAD, HNSC and THYM (Supplementary Figure S3). This evidence concerns the gene YTHDF2 and neoplasm.