ANXA2 and liver dysplastic nodule: In vitro study in human renal glomerular endothelial cells further validated that ANXA2 mediated mitomycin A-induced expression of collagen type VI and may contribute to DN pathogenesis since collagen type VI and phosphorylated histone H2AX, a DNA damage marker, were mainly detected in diabetic nodular glomerulosclerosis (Fujii et al., 2020).