ANXA2 and metastatic neoplasm: Ohno and colleagues investigated the expression of ANXA2 in clear cell RCC tissues and normal tissues, and detected upregulated expression of ANXA2 gene and protein in 14 of 18 primary RCC tissues, positive ANXA2 immunostaining in 73 of 154 primary RCC tissues, as well as 21 in 24 metastatic tumors.